Pub. Date : 2012 Nov
PMID : 22796153
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sorafenib attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats through suppression of JNK and MMP-9. | Sorafenib | matrix metallopeptidase 9 | Rattus norvegicus |
| 2 | Sorafenib also attenuated the activity of metallopeptidase-9 (MMP-9) and phosphorylation of c-Jun N-terminal kinase (JNK). | Sorafenib | matrix metallopeptidase 9 | Rattus norvegicus |
| 3 | CONCLUSIONS: Sorafenib reduced the severity of MCT-induced SOS in rats through suppression of MMP-9 and JNK activity, resulting in improvement of survival after hepatectomy. | Sorafenib | matrix metallopeptidase 9 | Rattus norvegicus |