Title : Benzimidazole-2-one: a novel anchoring principle for antagonizing p53-Mdm2.

Pub. Date : 2013 Jul 15

PMID : 22789708






2 Functional Relationships(s)
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1 Observing low muM affinities to mdm2 by NMR and fluorescence polarization we conclude that the 2-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetamide scaffold might be a good starting point to further optimize the affinities to Mdm2. 2-(2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)acetamide MDM2 proto-oncogene Homo sapiens
2 Observing low muM affinities to mdm2 by NMR and fluorescence polarization we conclude that the 2-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetamide scaffold might be a good starting point to further optimize the affinities to Mdm2. 2-(2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)acetamide MDM2 proto-oncogene Homo sapiens