Title : Electrostatic interactions play an essential role in the binding of oleic acid with α-lactalbumin in the HAMLET-like complex: a study using charge-specific chemical modifications.

Pub. Date : 2013 Jan

PMID : 22777854






3 Functional Relationships(s)
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1 Electrostatic interactions play an essential role in the binding of oleic acid with alpha-lactalbumin in the HAMLET-like complex: a study using charge-specific chemical modifications. Oleic Acid lactalbumin alpha Homo sapiens
2 Human alpha-lactalbumin made lethal to tumor cells (HAMLET) and its analogs are partially unfolded protein-oleic acid (OA) complexes that exhibit selective tumoricidal activity normally absent in the native protein itself. Oleic Acid lactalbumin alpha Homo sapiens
3 Retention of the positive charges by converting lysine residues to homoarginine groups (guanidination); however, yielded unchanged binding of OA to protein and identical tumoricidal activity to that displayed by the wild-type alpha-lactalbumin-oleic acid complex. Oleic Acid lactalbumin alpha Homo sapiens