Title : Acute O-GlcNAcylation prevents inflammation-induced vascular dysfunction.

Pub. Date : 2012 Sep 1

PMID : 22777418






2 Functional Relationships(s)
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1 We hypothesized that d-glucosamine (d-GlcN) and Thiamet-G, two agents that increase protein O-GlcNAcylation via different mechanisms, inhibit TNF-alpha-induced oxidative stress and vascular dysfunction by suppressing inducible nitric oxide (NO) synthase (iNOS) expression. thiamet G nitric oxide synthase 2 Homo sapiens
2 Expression of iNOS protein was increased in TNF-alpha-treated rings, and this was attenuated by pretreatment with either d-GlcN or Thiamet-G. thiamet G nitric oxide synthase 2 Homo sapiens