Pub. Date : 2012 Aug 24
PMID : 22773878
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fatty acids bind tightly to the N-terminal domain of angiopoietin-like protein 4 and modulate its interaction with lipoprotein lipase. | Fatty Acids | angiopoietin like 4 | Homo sapiens |
| 2 | In this study, we demonstrate that fatty acids reduce the inactivation of LPL by Angptl4. | Fatty Acids | angiopoietin like 4 | Homo sapiens |
| 3 | Surface plasmon resonance, isothermal titration calorimetry, fluorescence, and chromatography measurements revealed that fatty acids bind with high affinity to ccd-Angptl4. | Fatty Acids | angiopoietin like 4 | Homo sapiens |
| 4 | On binding of fatty acids, ccd-Angptl4 underwent conformational changes resulting in a decreased helical content, weakened structural stability, dissociation of oligomers, and altered fluorescence properties of the Trp-38 residue that is located close to the putative LPL-binding region. | Fatty Acids | angiopoietin like 4 | Homo sapiens |
| 5 | Based on these results, we propose that fatty acids play an important role in modulating the effects of Angptl4. | Fatty Acids | angiopoietin like 4 | Homo sapiens |