Protein Name angiopoietin like 4
Organism Homo sapiens
Gene ID 51129
Gene Symbol

ANGPTL4

UniProt Q9BY76 (ANGL4_HUMAN)
Relationships Total Number of functionally related compound(s) : 158
Total Number of Articles : 237
Description

angiopoietin like 4

Gene Summary

This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]

synonyms
  • angiopoietin-related protein 4
  • PPARG angiopoietin related protein
  • fasting-induced adipose factor
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Properties