Title : Metabotropic glutamate receptors inhibit microglial glutamate release.

Pub. Date : 2012 Aug 7

PMID : 22770428






2 Functional Relationships(s)
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1 Inhibition of cAMP-dependent protein kinase [also known as protein kinase A (PKA)] by H89 mimicked the effect of ACPD, and the mGluR agonist had its actions reversed by artificially sustaining cAMP through the PDE (phosphodiesterase) inhibitor IBMX (isobutylmethylxanthine) or the cAMP mimetic dbcAMP (dibutyryl cAMP). 1-Methyl-3-isobutylxanthine protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus
2 Inhibition of cAMP-dependent protein kinase [also known as protein kinase A (PKA)] by H89 mimicked the effect of ACPD, and the mGluR agonist had its actions reversed by artificially sustaining cAMP through the PDE (phosphodiesterase) inhibitor IBMX (isobutylmethylxanthine) or the cAMP mimetic dbcAMP (dibutyryl cAMP). 1-Methyl-3-isobutylxanthine protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus