Pub. Date : 2012 Jul 6
PMID : 22769244
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treating lung cancer cells with EGCG or C75 induced apoptosis and affected EGFR-signaling. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 2 | While EGCG abolished p-EGFR, p-AKT, p-ERK1/2 and p-mTOR, C75 was less active in decreasing the levels of EGFR and p-AKT. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 3 | CONCLUSIONS: In lung cancer, inhibition of FASN using EGCG can be achieved without parallel stimulation of fatty acid oxidation and this effect is related mainly to EGFR signaling pathway. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |