Pub. Date : 2012 Oct
PMID : 22767612
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Amiloride was the first organic blocker to selectively block the native T-type calcium channel, but the potency and mechanism of block of this drug on the three recombinant T-type calcium channels (Ca(V)3.1, Ca(V)3.2, and Ca(V)3.3) have not been systematically determined. | Amiloride | immunoglobulin lambda variable 7-43 | Homo sapiens |
| 2 | By performing whole-cell patch-clamp recordings of human embryonic kidney 293 cells stably expressing human Ca(V)3 channels, we found that amiloride blocked the human Ca(V)3 channels in a concentration-response manner; the IC50 for Ca(V)3.2 channels (62 muM) was 13-fold lower than that for Ca(V)3.1 and Ca(V)3.3. | Amiloride | immunoglobulin lambda variable 7-43 | Homo sapiens |
| 3 | The preferential block of Ca(V)3.2 channels labels amiloride as the only organic blocker to be selective for any T-type channel. | Amiloride | immunoglobulin lambda variable 7-43 | Homo sapiens |