Title : Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.

Pub. Date : 2012 Aug 24

PMID : 22767591






2 Functional Relationships(s)
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1 In these cells, IGF-I stimulation induced tyrosine phosphorylation of IGF-IR and IRS-1/2, but mutated IGF-IR failed to bind PI3K and to induce maximal phosphorylation of GSK3beta and cell proliferation in response to IGF-I. Tyrosine insulin like growth factor 1 Homo sapiens
2 In these cells, IGF-I stimulation induced tyrosine phosphorylation of IGF-IR and IRS-1/2, but mutated IGF-IR failed to bind PI3K and to induce maximal phosphorylation of GSK3beta and cell proliferation in response to IGF-I. Tyrosine insulin like growth factor 1 Homo sapiens