Pub. Date : 2012 Sep 5
PMID : 22766066
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Naringenin, the aglycone of naringin, has been reported to attenuate MUC5AC secretion by inhibiting activity of nuclear factor kappa B (NF-kappaB) via EGFR-PI3K-Akt/ERK MAPKinase signaling pathways. | naringin | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | The results showed that naringin of 100 muM not only significantly decreased EGF-induced overexpressions of both MUC5AC mucin and mRNA in A549 cells, but also suppressed the phosphorylation of EGF receptor, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK1/2), and c-Jun N-terminal kinase (JNK), as well as nucleus NF-kappaB p65 and AP-1. | naringin | mitogen-activated protein kinase 1 | Homo sapiens |