Pub. Date : 2012 Nov
PMID : 22750392
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GLP-1 completely blocked the angiotensin II-induced superoxide generation, NF-kappaB activation, up-regulation of mRNA levels of intercellular adhesion molecule-1 and plasminogen activator inhibitor-1 in mesangial cells, all of which were prevented by the treatments with H-89, an inhibitor of protein kinase A. | Superoxides | angiotensinogen | Homo sapiens |
| 2 | The present results demonstrated for the first time that GLP-1 blocked the angiotensin II-induced mesangial cell injury by inhibiting superoxide-mediated NF-kappaB activation via protein kinase C pathway. | Superoxides | angiotensinogen | Homo sapiens |