Title : High mobility group box-1 is phosphorylated by protein kinase C zeta and secreted in colon cancer cells.

Pub. Date : 2012 Jul 27

PMID : 22750245






3 Functional Relationships(s)
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Protein Name
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1 The serine residues at S39, S53 and S181 of HMGB1 were related to enhancing HMGB1 secretion. Serine high mobility group box 1 Homo sapiens
2 The serine residues at S39, S53 and S181 of HMGB1 were related to enhancing HMGB1 secretion. Serine high mobility group box 1 Homo sapiens
3 Our findings suggest that PKC-zeta is involved in the phosphorylation of HMGB1, and the phosphorylation of specific serine residues in the nuclear localization signal regions is related to enhanced HMGB1 secretion in colon cancer cells. Serine high mobility group box 1 Homo sapiens