Title : Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice.

Pub. Date : 2012 Aug

PMID : 22748276






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice. Cholesterol ATP-binding cassette, sub-family A (ABC1), member 2 Mus musculus
2 OBJECTIVE: The ABCA2 transporter shares high structural homology to ABCA1, which is crucial for the removal of excess cholesterol from macrophages and, by extension, in atherosclerosis. Cholesterol ATP-binding cassette, sub-family A (ABC1), member 2 Mus musculus
3 It has been suggested that ABCA2 sequesters cholesterol inside the lysosomes, however, little is known of the macrophage-specific role of ABCA2 in regulating lipid homeostasis in vivo and in modulating susceptibility to atherosclerosis. Cholesterol ATP-binding cassette, sub-family A (ABC1), member 2 Mus musculus