Pub. Date : 2012 Sep 1
PMID : 22740654
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation. | 5-hydroxymethyluracil | methyl-CpG binding domain 4, DNA glycosylase | Homo sapiens |
| 2 | MBD4 can excise the mismatched base paired with a guanine (G:X), where X is uracil, thymine or 5-hydroxymethyluracil (5hmU). | 5-hydroxymethyluracil | methyl-CpG binding domain 4, DNA glycosylase | Homo sapiens |
| 3 | MBD4 can excise the mismatched base paired with a guanine (G:X), where X is uracil, thymine or 5-hydroxymethyluracil (5hmU). | 5-hydroxymethyluracil | methyl-CpG binding domain 4, DNA glycosylase | Homo sapiens |
| 4 | MBD4 specifically recognizes the Watson-Crick polar edge of thymine or 5hmU via the O2, N3 and O4 atoms, thus restricting its activity to thymine/uracil-based modifications while excluding cytosine and its derivatives. | 5-hydroxymethyluracil | methyl-CpG binding domain 4, DNA glycosylase | Homo sapiens |