Title : Aromatic-turmerone attenuates invasion and expression of MMP-9 and COX-2 through inhibition of NF-κB activation in TPA-induced breast cancer cells.

Pub. Date : 2012 Dec

PMID : 22740037






2 Functional Relationships(s)
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1 Thus, transfection of breast cancer cells with PI3K/Akt and ERK1/2 siRNAs significantly decreased TPA-induced MMP-9 and COX-2 expression. Tetradecanoylphorbol Acetate AKT serine/threonine kinase 1 Homo sapiens
2 These results suggest that ar-turmerone suppressed the TPA-induced up-regulation of MMP-9 and COX-2 expression by blocking NF-kappaB, PI3K/Akt, and ERK1/2 signaling in human breast cancer cells. Tetradecanoylphorbol Acetate AKT serine/threonine kinase 1 Homo sapiens