Title : Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.

Pub. Date : 2012 Aug 31

PMID : 22730407






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The 3F-3DUrd monophosphate exhibits new inhibitory properties against a different enzyme of the pyrimidine nucleotide metabolism, namely the ODC activity of UMP synthase. monophosphate uridine monophosphate synthetase Homo sapiens