Pub. Date : 2012 Aug
PMID : 22714996
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 6-Gingerol and 6-shogaol concentrations of >= 10 muM and >= 2.5 muM, respectively, significantly inhibited the phosphorylation of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling, the activation of NF-kappaB, and the translocation of NF-kappaB and STAT3. | shogaol | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | 6-Gingerol and 6-shogaol concentrations of >= 10 muM and >= 2.5 muM, respectively, significantly inhibited the phosphorylation of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling, the activation of NF-kappaB, and the translocation of NF-kappaB and STAT3. | shogaol | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | CONCLUSION: 6-Shogaol and 6-gingerol effectively inhibit invasion and metastasis of hepatocellular carcinoma through diverse molecular mechanisms, including inhibition of the MAPK and PI3k/Akt pathways and NF-kappaB and STAT3 activities to suppress expression of MMP-2/-9 and uPA and block angiogenesis. | shogaol | nuclear factor kappa B subunit 1 | Homo sapiens |