Title : Gemfibrozil, a lipid-lowering drug, upregulates IL-1 receptor antagonist in mouse cortical neurons: implications for neuronal self-defense.

Pub. Date : 2012 Jul 15

PMID : 22706077






3 Functional Relationships(s)
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1 Gem also induced the activation of CREB via the PI3K-Akt pathway, and small interfering RNA attenuation of CREB abolished the gem-mediated increase in IL-1Ra. Gemfibrozil cAMP responsive element binding protein 1 Mus musculus
2 Gem also induced the activation of CREB via the PI3K-Akt pathway, and small interfering RNA attenuation of CREB abolished the gem-mediated increase in IL-1Ra. Gemfibrozil cAMP responsive element binding protein 1 Mus musculus
3 Taken together, these results highlight the importance of the PI3K-Akt-CREB pathway in mediating gem-induced upregulation of IL-1Ra in neurons and suggest gem as a possible therapeutic treatment for propagating neuronal self-defense in neuroinflammatory and neurodegenerative disorders. Gemfibrozil cAMP responsive element binding protein 1 Mus musculus