Pub. Date : 2012 Jul 15
PMID : 22706077
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present study underlines a novel application of gemfibrozil (gem), a Food and Drug Administration-approved lipid-lowering drug, in increasing the expression of IL-1Ra in primary mouse and human neurons. | Gemfibrozil | interleukin 1 receptor antagonist | Mus musculus |
| 2 | The present study underlines a novel application of gemfibrozil (gem), a Food and Drug Administration-approved lipid-lowering drug, in increasing the expression of IL-1Ra in primary mouse and human neurons. | Gemfibrozil | interleukin 1 receptor antagonist | Mus musculus |
| 3 | Activation of type IA p110alpha PI3K and Akt by gem and abrogation of gem-induced upregulation of IL-1Ra by inhibitors of PI3K and Akt indicate a role of the PI3K-Akt pathway in the upregulation of IL-1Ra. | Gemfibrozil | interleukin 1 receptor antagonist | Mus musculus |
| 4 | Activation of type IA p110alpha PI3K and Akt by gem and abrogation of gem-induced upregulation of IL-1Ra by inhibitors of PI3K and Akt indicate a role of the PI3K-Akt pathway in the upregulation of IL-1Ra. | Gemfibrozil | interleukin 1 receptor antagonist | Mus musculus |
| 5 | Gem also induced the activation of CREB via the PI3K-Akt pathway, and small interfering RNA attenuation of CREB abolished the gem-mediated increase in IL-1Ra. | Gemfibrozil | interleukin 1 receptor antagonist | Mus musculus |
| 6 | However, small interfering RNA knockdown of neuronal IL-1Ra abrogated the protective effect of gem against IL-1beta, suggesting that this drug increases the defense mechanism of cortical neurons via upregulation of IL-1Ra. | Gemfibrozil | interleukin 1 receptor antagonist | Mus musculus |
| 7 | However, small interfering RNA knockdown of neuronal IL-1Ra abrogated the protective effect of gem against IL-1beta, suggesting that this drug increases the defense mechanism of cortical neurons via upregulation of IL-1Ra. | Gemfibrozil | interleukin 1 receptor antagonist | Mus musculus |
| 8 | Taken together, these results highlight the importance of the PI3K-Akt-CREB pathway in mediating gem-induced upregulation of IL-1Ra in neurons and suggest gem as a possible therapeutic treatment for propagating neuronal self-defense in neuroinflammatory and neurodegenerative disorders. | Gemfibrozil | interleukin 1 receptor antagonist | Mus musculus |