Title : WNT-3a modulates platelet function by regulating small GTPase activity.

Pub. Date : 2012 Jul 30

PMID : 22705156






1 Functional Relationships(s)
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1 We observe WNT-3a to differentially regulate small GTPase activity in platelets, promoting the GDP-bound form of Rap1b to inhibit integrin-alpha(IIb)beta(3) adhesion, while concomitantly increasing Cdc42 and Rac1-GTP levels thereby disrupting normal platelet spreading. Guanosine Diphosphate cell division cycle 42 Homo sapiens