Title : Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia.

Pub. Date : 2012 Dec

PMID : 22700043






3 Functional Relationships(s)
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1 Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia. Clozapine 5-hydroxytryptamine receptor 3A Homo sapiens
2 Functionally important HTR3A gene single-nucleotide polymorphisms (SNPs) were reported to be associated with response to clozapine. Clozapine 5-hydroxytryptamine receptor 3A Homo sapiens
3 OBJECTIVE: The aim of this study was to investigate how the association between HTR3A gene SNP and response to clozapine is influenced by various clinical predictors and by differing outcome definitions in patients with treatment-resistant schizophrenia (TRS). Clozapine 5-hydroxytryptamine receptor 3A Homo sapiens