PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22685418-1	2012	Base-excision repair and control of nucleotide pools safe-guard against permanent uracil accumulation in DNA relying on two key enzymes: uracil-DNA glycosylase and dUTPase.	Uracil	82-88	Deoxyuridine triphosphatase	Drosophila melanogaster	164-171	
22685418-6	2012	We propose that the observed developmental pattern of uracil-DNA is due to the lack of the key repair enzyme UNG from the Drosophila genome together with down-regulation of dUTPase in larval tissues.	Uracil	54-60	Deoxyuridine triphosphatase	Drosophila melanogaster	173-180	
22685418-7	2012	In agreement, we show that dUTPase silencing increases the uracil content in DNA of imaginal tissues and induces strong lethality at the early pupal stages, indicating that tolerance of highly uracil-substituted DNA is also stage-specific.	Uracil	59-65	Deoxyuridine triphosphatase	Drosophila melanogaster	27-34	
22685418-7	2012	In agreement, we show that dUTPase silencing increases the uracil content in DNA of imaginal tissues and induces strong lethality at the early pupal stages, indicating that tolerance of highly uracil-substituted DNA is also stage-specific.	Uracil	193-199	Deoxyuridine triphosphatase	Drosophila melanogaster	27-34	
22685418-8	2012	Silencing of dUTPase perturbs the physiological pattern of uracil-DNA accumulation in Drosophila and leads to a strongly lethal phenotype in early pupal stages.	Uracil	59-65	Deoxyuridine triphosphatase	Drosophila melanogaster	13-20	
22685418-9	2012	These findings suggest a novel role of uracil-containing DNA in Drosophila development and metamorphosis and present a novel example for developmental effects of dUTPase silencing in multicellular eukaryotes.	Uracil	39-45	Deoxyuridine triphosphatase	Drosophila melanogaster	162-169