Title : Phosphorylation of adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif 1 (APPL1) at Ser430 mediates endoplasmic reticulum (ER) stress-induced insulin resistance in hepatocytes.

Pub. Date : 2012 Jul 27

PMID : 22685300






2 Functional Relationships(s)
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1 In addition, suppressing PKCalpha expression by shRNA in hepatocytes reduces ER stress-induced APPL1 phosphorylation at Ser(430) as well as the inhibitory effect of ER stress on insulin-stimulated Akt phosphorylation. Serine protein kinase C, alpha Mus musculus
2 Taken together, our results identify APPL1 as a novel target in ER stress-induced insulin resistance and PKCalpha as the kinase mediating ER stress-induced phosphorylation of APPL1 at Ser(430). Serine protein kinase C, alpha Mus musculus