Title : TNF-α inhibits PPARβ/δ activity and SIRT1 expression through NF-κB in human adipocytes.

Pub. Date : 2012 Sep

PMID : 22683888






2 Functional Relationships(s)
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1 Consistent with a role for NF-kappaB in the changes caused by TNF-alpha, treatment with the NF-kappaB inhibitor parthenolide restored PPAR DNA-binding activity, the expression of PPARbeta/delta-target genes and the expression of SIRT1 and PPARbeta/delta. parthenolide nuclear factor kappa B subunit 1 Homo sapiens
2 Consistent with a role for NF-kappaB in the changes caused by TNF-alpha, treatment with the NF-kappaB inhibitor parthenolide restored PPAR DNA-binding activity, the expression of PPARbeta/delta-target genes and the expression of SIRT1 and PPARbeta/delta. parthenolide nuclear factor kappa B subunit 1 Homo sapiens