Title : Pioglitazone, a PPAR-γ activator, attenuates the severity of cerulein-induced acute pancreatitis by modulating early growth response-1 transcription factor.

Pub. Date : 2012 Aug

PMID : 22677361






4 Functional Relationships(s)
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1 In vitro, a PPAR-gamma activator (pioglitazone) strikingly diminished Egr-1 mRNA and protein expression corresponding to Egr-1. Pioglitazone early growth response 1 Rattus norvegicus
2 In vitro, a PPAR-gamma activator (pioglitazone) strikingly diminished Egr-1 mRNA and protein expression corresponding to Egr-1. Pioglitazone early growth response 1 Rattus norvegicus
3 In vivo, treatment with pioglitazone prior to the intraperitoneal injection of cerulein induction of Egr-1 and its target genes such as, monocyte chemotactic protein-1 (MCP-1) and macrophage inflammatory protein-1 (MIP-1). Pioglitazone early growth response 1 Rattus norvegicus
4 The inhibitory effect of pioglitazone on Egr-1 expression induced by cerulein was almost fully restored by GW9662. Pioglitazone early growth response 1 Rattus norvegicus