Title : Divergence of Rho residue 43 impacts GEF activity.

Pub. Date : 2012 Jan-Mar

PMID : 22673745






1 Functional Relationships(s)
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1 Direct participation of residue 43 in GEF-catalyzed exchange was confirmed by the observation that mutation of this position to a threonine reduced GEF-catalyzed nucleotide exchange activity in vitro (Vav2, XPLN, GEFT, Dbl and Dbs) and greatly depressed RhoA and RhoC GTP-loading profiles in cell lysates. Threonine ras homolog family member A Homo sapiens