Pub. Date : 2012 Aug
PMID : 22669917
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We characterized ASBT orthologs from two primitive vertebrates, the lamprey that utilizes early 5alpha-bile alcohols and the skate that utilizes structurally different 5beta-bile alcohols, and compared substrate specificity with ASBT from humans who utilize modern 5beta-bile acids. | 5beta-bile alcohols | solute carrier family 10 member 2 | Homo sapiens |
| 2 | Cell-based assays using recombinant ASBT/Asbt"s indicate that lamprey Asbt has high affinity for 5alpha-bile alcohols, low affinity for 5beta-bile alcohols, and lacks affinity for TCA, whereas skate Asbt showed high affinity for 5alpha- and 5beta-bile alcohols but low affinity for TCA. | 5beta-bile alcohols | solute carrier family 10 member 2 | Homo sapiens |
| 3 | Cell-based assays using recombinant ASBT/Asbt"s indicate that lamprey Asbt has high affinity for 5alpha-bile alcohols, low affinity for 5beta-bile alcohols, and lacks affinity for TCA, whereas skate Asbt showed high affinity for 5alpha- and 5beta-bile alcohols but low affinity for TCA. | 5beta-bile alcohols | solute carrier family 10 member 2 | Homo sapiens |