Pub. Date : 2012 Aug 15
PMID : 22659162
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Atorvastatin preserves the integrity of endothelial adherens junctions by inhibiting vascular endothelial cadherin tyrosine phosphorylation. | Tyrosine | cadherin 5 | Homo sapiens |
| 2 | Vascular endothelial cadherin (VE-cad) tyrosine (Tyr) phosphorylation has been implicated in the disruption of adherens junctions (AJs) induced by inflammatory reactions. | Tyrosine | cadherin 5 | Homo sapiens |
| 3 | Vascular endothelial cadherin (VE-cad) tyrosine (Tyr) phosphorylation has been implicated in the disruption of adherens junctions (AJs) induced by inflammatory reactions. | Tyrosine | cadherin 5 | Homo sapiens |
| 4 | Vascular endothelial cadherin (VE-cad) tyrosine (Tyr) phosphorylation has been implicated in the disruption of adherens junctions (AJs) induced by inflammatory reactions. | Tyrosine | cadherin 5 | Homo sapiens |
| 5 | Vascular endothelial cadherin (VE-cad) tyrosine (Tyr) phosphorylation has been implicated in the disruption of adherens junctions (AJs) induced by inflammatory reactions. | Tyrosine | cadherin 5 | Homo sapiens |
| 6 | In ECs treated with interleukin (IL)-1beta for 30 min, VE-cad Tyr phosphorylation, dissociation of the VE-cad/beta-catenin complex and transendothelial migration (TEM) of monocytes were increased. | Tyrosine | cadherin 5 | Homo sapiens |
| 7 | Atorvastatin inhibited IL-1beta-induced Tyr phosphorylation of VE-cad by inhibiting RhoA and by dephosphorylating MLC. | Tyrosine | cadherin 5 | Homo sapiens |
| 8 | The attenuating effect of atorvastatin on VE-cad Tyr phosphorylation was reversed when RhoA was activated or MLC phosphatase was inhibited. | Tyrosine | cadherin 5 | Homo sapiens |
| 9 | Furthermore, inhibiting farnesyl transferase or geranylgeranyl transferase reproduced the inhibitory effects of atorvastatin on VE-cad Tyr phosphorylation. | Tyrosine | cadherin 5 | Homo sapiens |
| 10 | In addition, atorvastatin inhibited monocyte-induced VE-cad Tyr phosphorylation in ECs and attenuated IL-1beta-induced TEM of monocytes. | Tyrosine | cadherin 5 | Homo sapiens |
| 11 | Our study introduces a novel pleiotropic effect of atorvastatin and suggests that statins protect the integrity of AJs in ECs by inhibiting RhoA-mediated Tyr phosphorylation of VE-cad. | Tyrosine | cadherin 5 | Homo sapiens |