Protein Name cadherin 5
Organism Homo sapiens
Gene ID 1003
Gene Symbol

CDH5

UniProt P33151 (CADH5_HUMAN), Q59EA3 (Q59EA3_HUMAN)
Relationships Total Number of functionally related compound(s) : 327
Total Number of Articles : 418
Description

cadherin 5

Gene Summary

This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015]

synonyms
  • cadherin-5
  • 7B4 antigen
  • VE-cadherin
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Properties