Title : The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α.

Pub. Date : 2012 Jul 20

PMID : 22654113






1 Functional Relationships(s)
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1 Using the PPARalpha antagonist GW6471, we demonstrate that R(+)WIN55,212-2 acts via PPARalpha to activate JNK, activator protein-1, and positive regulatory domain IV to transcriptionally regulate the IFN-beta promoter. GW 6471 mitogen-activated protein kinase 8 Mus musculus