Title : Assessment of drug-drug interactions caused by metabolism-dependent cytochrome P450 inhibition.

Pub. Date : 2012 Jun 25

PMID : 22652334






1 Functional Relationships(s)
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1 R-fluoxetine and ticlopidine inhibited CYP2C19 activity, as determined using S-mephenytoin as a substrate, and caused 8.7- and 2.3-fold IC(50) shifts, respectively, after pre-incubation. Mephenytoin cytochrome P450 family 2 subfamily C member 19 Homo sapiens