Title : TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers.

Pub. Date : 2013 Mar 21

PMID : 22641218






1 Functional Relationships(s)
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1 Celastrol, a TAK1 inhibitor and anti-inflammatory compound used in traditional Chinese medicine, also decreased TGF-beta1-induced phosphorylation of TAK1 and RELA, and suppressed basal, TGF-beta1- and tumor necrosis factor-alpha (TNF-alpha)-induced NF-kappaB reporter gene activity. celastrol RELA proto-oncogene, NF-kB subunit Homo sapiens