Pub. Date : 2012 May 28
PMID : 22640878
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: The extracellular matrix (ECM) has a key role in facilitating the progression of ovarian cancer and we have shown recently that the secreted ECM protein TGFBI modulates the response of ovarian cancer to paclitaxel-induced cell death. | Paclitaxel | transforming growth factor beta induced | Homo sapiens |
| 2 | CONCLUSIONS: Therefore, different ECM components use distinct signaling mechanisms in ovarian cancer cells and in particular, TGFBI preferentially interacts through a ss3 integrin receptor mediated mechanism to regulate the response of cells to paclitaxel-induced cell death. | Paclitaxel | transforming growth factor beta induced | Homo sapiens |