Title : SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of β-catenin.

Pub. Date : 2012 Jun 29

PMID : 22640743






1 Functional Relationships(s)
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1 It was reported that inhibition of GSK-3beta or Siah-1 stabilizes beta-catenin in colon cancer cells, but suppression of GSK-3beta or Siah-1 using siRNA in the presence of resveratrol instead diminished beta-catenin protein levels in Panc-PAUF cells. Resveratrol glycogen synthase kinase 3 beta Homo sapiens