Title : Ebselen inhibits iron-induced tau phosphorylation by attenuating DMT1 up-regulation and cellular iron uptake.

Pub. Date : 2012 Aug

PMID : 22634399






4 Functional Relationships(s)
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1 We have recently reported that divalent metal transporter 1 (DMT1) is upregulated in an AD transgenic mouse brain, and that silencing of DMT1, which reduces cellular iron influx, results in inhibition of amyloidogenesis in vitro, suggesting a potential target of DMT1 for AD therapy. Iron solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Mus musculus
2 We have recently reported that divalent metal transporter 1 (DMT1) is upregulated in an AD transgenic mouse brain, and that silencing of DMT1, which reduces cellular iron influx, results in inhibition of amyloidogenesis in vitro, suggesting a potential target of DMT1 for AD therapy. Iron solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Mus musculus
3 We have recently reported that divalent metal transporter 1 (DMT1) is upregulated in an AD transgenic mouse brain, and that silencing of DMT1, which reduces cellular iron influx, results in inhibition of amyloidogenesis in vitro, suggesting a potential target of DMT1 for AD therapy. Iron solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Mus musculus
4 We have recently reported that divalent metal transporter 1 (DMT1) is upregulated in an AD transgenic mouse brain, and that silencing of DMT1, which reduces cellular iron influx, results in inhibition of amyloidogenesis in vitro, suggesting a potential target of DMT1 for AD therapy. Iron solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Mus musculus