Pub. Date : 2012 Dec
PMID : 22632894
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Superoxide dismutase (SOD) is a major defender against excessive superoxide generated under hyperglycemia. | Superoxides | superoxide dismutase 1, soluble | Mus musculus |
| 2 | Increased glomerular superoxide levels were observed in SOD1(-/-)SOD3(+/+) and SOD1(-/-)SOD3(-/-) C57BL/6-Akita mice but not in SOD1(+/+)SOD3(-/-) C57BL/6-Akita mice. | Superoxides | superoxide dismutase 1, soluble | Mus musculus |
| 3 | Increased glomerular superoxide levels were observed in SOD1(-/-)SOD3(+/+) and SOD1(-/-)SOD3(-/-) C57BL/6-Akita mice but not in SOD1(+/+)SOD3(-/-) C57BL/6-Akita mice. | Superoxides | superoxide dismutase 1, soluble | Mus musculus |
| 4 | Increased glomerular superoxide levels were observed in SOD1(-/-)SOD3(+/+) and SOD1(-/-)SOD3(-/-) C57BL/6-Akita mice but not in SOD1(+/+)SOD3(-/-) C57BL/6-Akita mice. | Superoxides | superoxide dismutase 1, soluble | Mus musculus |
| 5 | The present results demonstrate that deficiency of SOD1, but not SOD3, increases renal superoxide in the setting of diabetes and causes overt renal injury in nephropathy-resistant diabetic mice, and that SOD3 deficiency does not provide additive effects on the severity of DN in SOD1-deficient C57BL/6-Akita mice. | Superoxides | superoxide dismutase 1, soluble | Mus musculus |