Title : Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43.

Pub. Date : 2012 Sep 1

PMID : 22623726






4 Functional Relationships(s)
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1 Here, we demonstrate by live-cell imaging analysis that treatment of cells with 12-O-tetradecanoylphorbol 13-acetate (TPA) induces endocytosis of subdomains of connexin43 gap junctions. Tetradecanoylphorbol Acetate gap junction protein alpha 1 Homo sapiens
2 Here, we demonstrate by live-cell imaging analysis that treatment of cells with 12-O-tetradecanoylphorbol 13-acetate (TPA) induces endocytosis of subdomains of connexin43 gap junctions. Tetradecanoylphorbol Acetate gap junction protein alpha 1 Homo sapiens
3 The HECT E3 ubiquitin ligase smad ubiquitination regulatory factor-2 (Smurf2) was found to be recruited to connexin43 gap junctions in response to TPA treatment. Tetradecanoylphorbol Acetate gap junction protein alpha 1 Homo sapiens
4 Smurf2 depletion also counteracted the TPA-induced endocytosis and degradation of connexin43. Tetradecanoylphorbol Acetate gap junction protein alpha 1 Homo sapiens