Pub. Date : 2012 Jul
PMID : 22617226
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of CYP induction by rifampicin on tamoxifen exposure. | Tamoxifen | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 2 | We evaluated the effects of cytochrome P450 (CYP) induction by rifampicin on the exposure levels of tamoxifen and its metabolites and found that coadministration of rifampicin resulted in markedly reduced (up to 86%, P <= 0.040) concentrations of tamoxifen and its metabolites. | Tamoxifen | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 3 | We evaluated the effects of cytochrome P450 (CYP) induction by rifampicin on the exposure levels of tamoxifen and its metabolites and found that coadministration of rifampicin resulted in markedly reduced (up to 86%, P <= 0.040) concentrations of tamoxifen and its metabolites. | Tamoxifen | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 4 | We evaluated the effects of cytochrome P450 (CYP) induction by rifampicin on the exposure levels of tamoxifen and its metabolites and found that coadministration of rifampicin resulted in markedly reduced (up to 86%, P <= 0.040) concentrations of tamoxifen and its metabolites. | Tamoxifen | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 5 | Similar drug-drug interactions may exist between tamoxifen and other strong CYP inducers. | Tamoxifen | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |