Title : Progesterone and calcitriol attenuate inflammatory cytokines CXCL1 and CXCL2 in ovarian and endometrial cancer cells.

Pub. Date : 2012 Oct

PMID : 22615136






4 Functional Relationships(s)
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1 Knockdown of NFkappaB resulted in a reduced expression of CXCL1 and CXCL2 and the inhibitory effect of progesterone and calcitriol on the expression of chemokines was abrogated in NFkappaB-silenced cancer cells. Progesterone nuclear factor kappa B subunit 1 Homo sapiens
2 Knockdown of NFkappaB resulted in a reduced expression of CXCL1 and CXCL2 and the inhibitory effect of progesterone and calcitriol on the expression of chemokines was abrogated in NFkappaB-silenced cancer cells. Progesterone nuclear factor kappa B subunit 1 Homo sapiens
3 Overall, our results indicate that progesterone and calcitriol inhibit IkappaBalpha phosphorylation, NFkappaB activation, and the expression of NFkappaB regulated metastasis promoting genes. Progesterone nuclear factor kappa B subunit 1 Homo sapiens
4 Overall, our results indicate that progesterone and calcitriol inhibit IkappaBalpha phosphorylation, NFkappaB activation, and the expression of NFkappaB regulated metastasis promoting genes. Progesterone nuclear factor kappa B subunit 1 Homo sapiens