Title : Epitope targeting and viral inoculum are determinants of Nef-mediated immune evasion of HIV-1 from cytotoxic T lymphocytes.

Pub. Date : 2012 Jul 5

PMID : 22613796






5 Functional Relationships(s)
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Protein Name
Organism
1 Whereas Gag-specific CTLs generally were less susceptible to Nef than those targeting other proteins, this was determined by the ability to eliminate infected cells before de novo synthesis of viral proteins, which was also observed for CTLs targeting a Nef epitope. Glycosaminoglycans S100 calcium binding protein B Homo sapiens
2 Whereas Gag-specific CTLs generally were less susceptible to Nef than those targeting other proteins, this was determined by the ability to eliminate infected cells before de novo synthesis of viral proteins, which was also observed for CTLs targeting a Nef epitope. Glycosaminoglycans S100 calcium binding protein B Homo sapiens
3 These results suggest that whereas Gag-specific CTLs are more likely to recognize infected cells before Nef-mediated HLA-I down-regulation, this varies depending on the specific epitope and virus inoculum. Glycosaminoglycans S100 calcium binding protein B Homo sapiens
4 Reduced susceptibility to Nef therefore may contribute to the overall association of Gag-specific CTL responses to better immune control if a sufficient multiplicity of infection is attained in vivo, but this property is not unique to Gag. Glycosaminoglycans S100 calcium binding protein B Homo sapiens
5 Reduced susceptibility to Nef therefore may contribute to the overall association of Gag-specific CTL responses to better immune control if a sufficient multiplicity of infection is attained in vivo, but this property is not unique to Gag. Glycosaminoglycans S100 calcium binding protein B Homo sapiens