Title : Dehydroepiandrosterone indirectly inhibits human osteoclastic resorption via activating osteoblastic viability by the MAPK pathway.

Pub. Date : 2012 Apr

PMID : 22613593






2 Functional Relationships(s)
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1 Within the effective concentration range, the expression of phosphor-ERK1/2 and osteoprotegerin was increased by DHEA and blocked by U0126. Dehydroepiandrosterone TNF receptor superfamily member 11b Homo sapiens
2 CONCLUSIONS: DHEA could indirectly inhibit the human osteoclastic resorption through promoting the osteoblastic viability and osteoprotegerin production, which is mediated by mitogen-activated protein kinases signal pathway involving the phosphor-ERK1/2. Dehydroepiandrosterone TNF receptor superfamily member 11b Homo sapiens