Title : Covalent modification and time-dependent inhibition of human CYP2E1 by the meta-isomer of acetaminophen.

Pub. Date : 2012 Aug

PMID : 22613176






2 Functional Relationships(s)
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1 Covalent modification and time-dependent inhibition of human CYP2E1 by the meta-isomer of acetaminophen. Acetaminophen cytochrome P450 family 2 subfamily E member 1 Homo sapiens
2 The hypothesis that N-acetyl-m-aminophenol (AMAP), the meta isomer of acetaminophen, will covalently bind to and inhibit human CYP2E1 in a time- and NADPH-dependent manner was investigated. Acetaminophen cytochrome P450 family 2 subfamily E member 1 Homo sapiens