Title : Epidermal growth factor regulates connexin 43 in the human epididymis: role of gap junctions in azoospermia.

Pub. Date : 2012 Aug

PMID : 22611165






2 Functional Relationships(s)
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1 Furthermore, while the phosphoinositide-3-kinase (PI3K)/AKT signaling pathway did not alter GJA1 phosphorylation, treatment with PI3K/AKT inhibitor LY294002 significantly (P=0.024) inhibited the EGF-stimulated increase in GJA1 total protein levels at 24 h. Immunolocalization indicated that loss of PI3K/AKT signaling was associated with increased cytosolic localization of Cx43 in this cell line. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one gap junction protein alpha 1 Homo sapiens
2 Furthermore, while the phosphoinositide-3-kinase (PI3K)/AKT signaling pathway did not alter GJA1 phosphorylation, treatment with PI3K/AKT inhibitor LY294002 significantly (P=0.024) inhibited the EGF-stimulated increase in GJA1 total protein levels at 24 h. Immunolocalization indicated that loss of PI3K/AKT signaling was associated with increased cytosolic localization of Cx43 in this cell line. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one gap junction protein alpha 1 Homo sapiens