Title : Suppression of ribosomal function triggers innate immune signaling through activation of the NLRP3 inflammasome.

Pub. Date : 2012

PMID : 22606244






2 Functional Relationships(s)
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1 Some inflammatory stimuli trigger activation of the NLRP3 inflammasome by inducing efflux of cellular potassium. Potassium NLR family, pyrin domain containing 3 Mus musculus
2 Despite the inability of these inhibitors to trigger efflux of intracellular potassium, the addition of high extracellular potassium suppressed activation of the NLRP3 inflammasome. Potassium NLR family, pyrin domain containing 3 Mus musculus