Pub. Date : 2012 Jun 22
PMID : 22584582
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Successive phosphorylation of p27(KIP1) protein at serine-10 and C terminus crucially controls its potency to inactivate Cdk2. | Serine | cyclin dependent kinase 2 | Homo sapiens |
| 2 | During the G(1)-S transition, the activity of Cdk2 is regulated by its association with p27(KIP1), which in rodent fibroblasts undergoes phosphorylation mainly at serine 10, threonine 187, and C-terminal threonine 197 by KIS, Cdk2, and Pim or ROCK, respectively. | Serine | cyclin dependent kinase 2 | Homo sapiens |
| 3 | We report here that serine 10 phosphorylation is required for efficient C-terminal phosphorylation of its own by PIM and ROCK kinases and critically controls the potency of p27 as a Cdk2 inhibitor. | Serine | cyclin dependent kinase 2 | Homo sapiens |