Pub. Date : 2012 Jun 29
PMID : 22580326
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sevoflurane postconditioning involves an up-regulation of HIF-1alpha and HO-1 expression via PI3K/Akt pathway in a rat model of focal cerebral ischemia. | Sevoflurane | heme oxygenase 1 | Rattus norvegicus |
| 2 | In this study, we tested the hypothesis that sevoflurane postconditioning induces neuroprotection through the up-regulation hypoxia inducible factor-1alpha (HIF-1alpha) and heme oxygenase-1 (HO-1) involving phosphatidylinositol-3-kinase (PI3K)/Akt pathway. | Sevoflurane | heme oxygenase 1 | Rattus norvegicus |
| 3 | In this study, we tested the hypothesis that sevoflurane postconditioning induces neuroprotection through the up-regulation hypoxia inducible factor-1alpha (HIF-1alpha) and heme oxygenase-1 (HO-1) involving phosphatidylinositol-3-kinase (PI3K)/Akt pathway. | Sevoflurane | heme oxygenase 1 | Rattus norvegicus |
| 4 | In the second experiment, we investigated the relationship between PI3K/Akt pathway and the expression of HIF-1alpha and HO-1 in the neuroprotection induced by sevoflurane. | Sevoflurane | heme oxygenase 1 | Rattus norvegicus |
| 5 | Compared with the control group, sevoflurane postconditiong significantly ameliorated neuronal injury, up-regulated mRNA and protein levels of HIF-1alpha and HO-1, inhibited the activity of caspase-3, and decreased the number of TUNEL-positive cells and infarct sizes. | Sevoflurane | heme oxygenase 1 | Rattus norvegicus |
| 6 | However, the selective PI3K inhibitor, wortmannin not only partly eliminated the neuroprotection of sevoflurane as shown by reducing infarct size and apoptotic neuronal cells, but also reversed the elevation of HIF-1alpha, HO-1 and p-Akt expression in the ischemic penumbra induced by sevoflurane. | Sevoflurane | heme oxygenase 1 | Rattus norvegicus |
| 7 | Therefore, our data demonstrate that the cerebral protection from sevoflurane postconditioning is partly mediated by PI3K/Akt pathway via the up-regulation of HIF-1alpha and HO-1. | Sevoflurane | heme oxygenase 1 | Rattus norvegicus |