Title : Tramadol pretreatment enhances ketamine-induced antidepressant effects and increases mammalian target of rapamycin in rat hippocampus and prefrontal cortex.

Pub. Date : 2012

PMID : 22577289






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1 Pretreatment with tramadol enhances the ketamine-induced antidepressant effects, which is associated with the increased expression of mTOR in rat hippocampus and prefrontal cortex. Ketamine mechanistic target of rapamycin kinase Rattus norvegicus