Title : Anti-benzopyrene-7,8-diol-9,10-epoxide induces apoptosis via mitochondrial pathway in human bronchiolar epithelium cells independent of the mitochondria permeability transition pore.

Pub. Date : 2012 Jul

PMID : 22565279






1 Functional Relationships(s)
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1 In conclusion, these results suggest that BPDE-mediated apoptosis occurs via caspase-9 dependent mitochondria pathway associated with ROS formation, loss of DeltaPsi(m), up-regulation of p53 and down-regulation of c-Myc, but independent of the opening of mPTP in 16HBE cells. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide caspase 9 Homo sapiens