Title : In utero nicotine exposure promotes M2 activation in neonatal mouse alveolar macrophages.

Pub. Date : 2012 Aug

PMID : 22562289






2 Functional Relationships(s)
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1 However, AMs from mice deficient in the alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) had less TGFbeta1, reduced alternative activation, and improved phagocytic functioning despite similar in utero nicotine exposure. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 CONCLUSION: In utero nicotine exposure, mediated in part via the alpha7 nAChR, may increase the risk of lower respiratory tract infections in neonates by changing the resting state of AM toward alternative activation. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus